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Table 2 Differentially expressed proteins in SFTS patients

From: Serum proteomics of severe fever with thrombocytopenia syndrome patients

Uniprot_Id

Description

Gene

Recovered patients/normal subjects

Deceased patients/recovered patients

p-value

log2FC

p-value

log2FC

Complement system

  

P09871

Complement C1s subcomponent

C1S

1.0E−05

5.666

2.2E−07

− 5.847

P13671

Complement component C6

C6

3.2E−06

− 1.882

0.0031

− 4.564

P10643

Complement component C7

C7

0.0168

− 1.125

0.0008

− 4.422

A0A3B3ISR2

Complement subcomponent C1r

C1R

2.2E−05

5.615

7.9E−06

− 2.897

P0C0L5

Complement C4-B

C4B

0.0092

0.867

0.0002

− 1.774

P0C0L4

Complement C4-A

C4A

4.8E−07

2.138

0.0001

− 1.44

P02748

Complement component C9

C9

0.4626

− 0.243

0.024

− 1.089

P11215

Integrin alpha-M

ITGAM

  

0.4126

− 0.598

Q5SR44

Complement receptor type 1

CR1

  

0.1442

1.494

O00187

Mannan-binding lectin serine protease 2

MASP2

0.0048

1.702

0.0323

4.416

Coagulation system

 

A0A3B3ISJ1

Vitamin K-dependent protein S

PROS1

1.7E−05

2.286

1.7E−10

− 6.992

E7END6

Vitamin K-dependent protein C

PROC

0.0008

2.107

1.4E−05

− 4.393

P05546

Heparin cofactor 2

SERPIND1

0.716

− 0.111

0.0021

− 3.98

P01023

Alpha-2-macroglobulin

A2M

0.4494

0.121

0.0026

− 3.198

P12259

Coagulation factor V

F5

0.1737

1.225

0.0159

− 2.542

P04275

von Willebrand factor

VWF

0.5524

0.697

0.1201

− 1.945

P00740

Coagulation factor IX

F9

0.0348

1.425

0.0194

− 1.564

P01009

Alpha-1-antitrypsin

SERPINA1

0.4545

− 0.447

0.8891

0.092

P01008

Antithrombin-III

SERPINC1

0.2133

− 0.525

0.4596

0.272

P08697

Alpha-2-antiplasmin

SERPINF2

0.0001

− 2.042

0.273

0.541

P05154

Plasma serine protease inhibitor

SERPINA5

0.8133

− 0.168

0.0001

5.42

Downstream target of TNF-α and IL-1β

 

P05109

Protein S100-A8

S100A8

0.0065

3.536

0.0445

3.82

P06702

Protein S100-A9

S100A9

0.0005

4.66

0.0708

2.681

P02647

Apolipoprotein A-I

APOA1

0.0077

− 0.859

0.0003

− 3.788

P02649

Apolipoprotein E

APOE

0.0525

0.935

1.1E−07

− 5.696