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Table 1 The indicators of vascular injury

From: Proteomics-based evaluation of the mechanism underlying vascular injury via DNA interstrand crosslinks, glutathione perturbation, mitogen-activated protein kinase, and Wnt and ErbB signaling pathways induced by crotonaldehyde

GO analysis

Protein accession

Protein

Gene

FC1

FC2

Node

DNA damage and repair

Q5TG38

DNA methyltransferase 1-associated protein 1 (Fragment)

DMAP1

0.52

0.45

1

Q9BY89

Uncharacterized protein KIAA1671

KIAA1671

2.54

2.36

0

D3DXI9

DNA polymerase epsilon catalytic subunit

POLE

1.86

1.69

0

F8WBH5

Proteasome activator complex subunit 4

PSME4

2.16

1.99

0

P01023

Alpha-2-macroglobulin

A2M

1.80

2.04

4

Q8TC04

Keratin 23 (Histone deacetylase inducible)

KRT23

0.65

0.59

1

Oxidation–reduction process

H0YL12

Electron transfer flavoprotein subunit alpha, mitochondrial (Fragment)

ETFA

2.03

1.87

3

O95101

Cytochrome c oxidase subunit

N/A

0.56

0.51

0

B4DWB3

cDNA FLJ61432, highly similar to Transient receptor potential cation channel subfamily M member 2

 

0.49

0.44

0

Mitochondrial

P48507

Glutamate–cysteine ligase regulatory subunit

GCLM

1.88

2.04

1

E7EVY0

Mitochondrial inner membrane protein OXA1L

OXA1L

1.82

1.76

4

H0YEL3

V-type proton ATPase subunit a (Fragment)

TCIRG1

0.00

0.14

0

Arterial dysfunction

B4DFV1

Protein kinase C (EC 2.7.11.13)

 

0.45

0.31

0

P48507a

Glutamate–cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate–cysteine ligase modifier subunit)

GCLM GLCLR

1.88

2.04

1

Vascular remodeling

B4DI57

cDNA FLJ54111, highly similar to Serotransferrin

N/A

2.32

1.96

0

B4DV58

cDNA FLJ55250, highly similar to Cytochrome P450 4B1

N/A

1.52

1.72

0

C9J080

Beta-adducin (Fragment)

ADD2

0.00

0.11

0

P05109

Protein S100-A8

S100A8

0.66

0.57

1

Q8TC04a

Keratin 23 (Histone deacetylase inducible)

KRT23

0.65

0.59

1

A0A1B0GV06

Acid ceramidase (Fragment)

ASAH1

0.00

0.05

1

Un-integrity and dysfunction of HAECs

P48507a

Glutamate–cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate–cysteine ligase modifier subunit)

GCLM

1.88

2.04

1

A0A0X1KG69

InaD-like protein

PATJ

3.27

2.79

0

E9PP49

Collagen alpha-2(VIII) chain (Collagen type VIII alpha 2)

COL8A2

2.21

2.54

0

Lipid metabolism

P19838

Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]

NFKB1

0.42

0.55

0

A0A2P9AF66

3′(2′),5′-bisphosphate nucleotidase CysQ

cysQ

1.75

2.01

0

B4DJ23

Myotubularin-related protein 14 (cDNA FLJ52857)

MTMR14

0.16

0.12

0

A0A2P9AJA0

Histidine kinase

BQ8482_180436

2.78

3.25

0

Immunity and autophagy

P19838a

Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]

NFKB1

0.42

0.55

0

P05109a

Protein S100-A8

S100A8

0.66

0.57

1

P05546

Heparin cofactor 2

SERPIND1 HCF2

2.28

2.05

1

B4DJ23a

Myotubularin-related protein 14 (cDNA FLJ52857)

MTMR14

0.16

0.12

0

P02765

Alpha-2-HS-glycoprotein

AHSG

2.19

1.96

7

MAPK cascade

B4DI57a

cDNA FLJ54111, highly similar to Serotransferrin

N/A

2.32

1.96

0

P19838a

Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1)

NFKB1

0.42

0.55

0

Q9UPS8

Ankyrin repeat domain-containing protein 26

ANKRD26

1.68

1.73

1

Blood coagulation

B4DPN0

cDNA FLJ51265, moderately similar to Beta-2-glycoprotein 1 (Beta-2-glycoprotein I)

N/A

1.56

1.68

0

P05546a

Heparin cofactor 2

SERPIND1 HCF2

2.28

2.05

1

P02765a

Alpha-2-HS-glycoprotein

AHSG

2.19

1.96

7

Q13797

Integrin alpha-9 (Integrin alpha-RLC)

ITGA9

1.97

2.14

0

ERBB

B4DFV1a

Protein kinase C (EC 2.7.11.13)

N/A

0.45

0.31

0

Q96CD4

Similar to breast cancer anti-estrogen resistance 1

N/A

1.65

1.51

0

Q9Y4L5

E3 ubiquitin-protein ligase RNF115

RNF115

1.82

2.21

3

Wnt signaling pathway

A0A024R2V4

Coiled-coil domain containing 51, isoform CRA_a

CCDC51

1.67

1.59

0

P19838a

Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]

NFKB1

0.42

0.55

0

Q8N7H5

RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2)

PAF1 PD2

0.66

0.53

0

B4DI57a

cDNA FLJ54111, highly similar to Serotransferrin

N/A

2.32

1.96

0

Q4ZG84

Submitted name: Uncharacterized protein LRP2

LRP2

1.55

1.86

6

  1. FC1 determination the FC with TMT-based proteomics analysis; FC2 validation of FC1 by PRM method
  2. aThis protein occurs more than once
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Clinical Proteomics

ISSN: 1559-0275