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Fig. 2 | Clinical Proteomics

Fig. 2

From: Identification of novel proteins in inflammatory bowel disease based on the gut-brain axis: a multi-omics integrated analysis

Fig. 2

Manhattan plots of PWAS and TWAS for inflammatory bowel disease and its subtypes. Manhattan plots depict significant human brain proteins and genes discovered in PWAS and TWAS for IBD and its subtypes. Each point represents a single test of association between a gene and phenotype, plotted based on genomic position on the x-axis and Z-value on the y-axis. Statistically significant proteins and genes identified through analysis are plotted, with annotated regions denoting those that have been validated. Proteins identified in both discovery PWAS and confirmation PWAS are highlighted in red and blue fonts, with red representing Banner in discovery PWAS and blue representing ROSMAP in confirmation PWAS. Green font indicates genes significantly identified in TWAS analysis of proteins validated by PWAS. Subplots are labeled for IBD, CD, and UC

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Clinical Proteomics

ISSN: 1559-0275