Table 2 Mendelian randomization analysis validating causal relationships at the proteomic level
Exposure | Method | Beta | Se | Pval | OR(95%CI) |
|---|---|---|---|---|---|
IBD | |||||
LSP1 | Wald ratio | 0.44 | 0.10 | 8.30E-06 | 1.55(1.28,1.89) |
LNPEP | Wald ratio | -2.20 | 0.47 | 3.54E-06 | 0.11(0.04,0.28) |
TYK2 | Wald ratio | -0.93 | 0.14 | 6.75E-11 | 0.39(0.29,0.52) |
GPX1 | Wald ratio | -1.35 | 0.15 | 6.50E-20 | 0.25(0.19,0.34) |
SULT1A1 | Wald ratio | -0.38 | 0.07 | 9.15E-09 | 0.68(0.60,0.77) |
FDPS | Wald ratio | -0.81 | 0.18 | 6.63E-06 | 0.44(0.31,0.63) |
GPSM1 | Wald ratio | -1.48 | 0.47 | 1.56E-03 | 0.22(0.09,0.56) |
AUH | Wald ratio | -1.57 | 0.34 | 3.45E-06 | 0.20(0.10,0.40) |
INPP5E | Wald ratio | -1.84 | 0.26 | 2.11E-12 | 0.15(0.09,0.26) |
CD | |||||
FDPS | Wald ratio | -1.32 | 0.24 | 5.72E-08 | 0.26(0.16,0.42) |
INPP5E | Wald ratio | -2.22 | 0.35 | 3.80E-10 | 0.10(0.05,0.21) |
PDLIM4 | Wald ratio | -0.72 | 0.18 | 4.87E-05 | 0.48(0.34,0.68) |
GPX1 | Wald ratio | -1.38 | 0.20 | 7.14E-12 | 0.25(0.17,0.37) |
SULT1A1 | Wald ratio | -0.50 | 0.09 | 3.37E-08 | 0.60(0.51,0.72) |
HINT1 | Wald ratio | -2.19 | 0.48 | 6.16E-06 | 0.11(0.04,0.28) |
UC | |||||
GPX1 | Wald ratio | -1.30 | 0.19 | 2.48E-12 | 0.27(0.19,0.39) |
LSP1 | Wald ratio | 0.59 | 0.12 | 8.43E-07 | 1.80(1.42,2.28) |
AUH | Wald ratio | -1.76 | 0.43 | 3.61E-05 | 0.17(0.07,0.39) |
PANK4 | Wald ratio | -1.70 | 0.73 | 0.02 | 0.18(0.04,0.76) |
INPP5E | Wald ratio | -1.44 | 0.33 | 1.11E-05 | 0.23(0.12,0.45) |