Table 1 Prevalent Pathway of CB-PRP contents

R-HSA-2168880

Scavenging of heme from plasma

25

99

4,33E-15

R-HSA-166786

Creation of C4 and C2 activators

25

103

4,33E-15

R-HSA-173623

Classical antibody-mediated complement activation

23

95

4,33E-15

R-HSA-166658

Complement cascade

48

146

4,33E-15

R-HSA-977606

Regulation of Complement cascade

46

135

4,33E-15

R-HSA-166663

Initial triggering of complement

28

111

4,33E-15

R-HSA-2173782

Binding and Uptake of Ligands by Scavenger Receptors

31

129

4,33E-15

R-HSA-140877

Formation of Fibrin Clot (Clotting Cascade)

20

39

4,33E-15

R-HSA-114608

Platelet degranulation

50

128

4,33E-15

R-HSA-76005

Response to elevated platelet cytosolic Ca2 + 

50

133

4,33E-15

R-HSA-109582

Hemostasis

85

726

4,33E-15

R-HSA-76002

Platelet activation, signaling and aggregation

55

265

4,33E-15

R-HSA-168249

Innate Immune System

85

1197

4,33E-15

R-HSA-168256

Immune System

97

2188

4,33E-15

R-HSA-140875

Common Pathway of Fibrin Clot Formation

13

22

2,88E-14

R-HSA-140837

Intrinsic Pathway of Fibrin Clot Formation

13

23

4,91E-14

R-HSA-381426

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

22

124

1,63E-13

R-HSA-5690714

CD22 mediated BCR regulation

17

70

1,61E-12

R-HSA-2029481

FCGR activation

19

101

4,16E-12

R-HSA-2029482

Regulation of actin dynamics for phagocytic cup formation

22

150

5,94E-12

R-HSA-8957275

Post-translational protein phosphorylation

19

107

1,01E-11

R-HSA-2029485

Role of phospholipids in phagocytosis

19

114

2,89E-11

R-HSA-2029480

Fcgamma receptor (FCGR) dependent phagocytosis

22

175

1,04E-10

R-HSA-166665

Terminal pathway of complement

8

8

1,17E-10

R-HSA-983695

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

17

95

1,36E-10

R-HSA-9664323

FCGR3A-mediated IL10 synthesis

19

128

1,74E-10

R-HSA-202733

Cell surface interactions at the vascular wall

25

246

2,45E-10

R-HSA-9664417

Leishmania phagocytosis

20

149

2,45E-10

R-HSA-9664407

Parasite infection

20

149

2,45E-10

R-HSA-9664422

FCGR3A-mediated phagocytosis

20

149

2,45E-10

R-HSA-9664433

Leishmania parasite growth and survival

20

168

1,86E-09

R-HSA-9662851

Anti-inflammatory response favouring Leishmania parasite infection

20

168

1,86E-09

R-HSA-8963898

Plasma lipoprotein assembly

9

19

2,65E-09

R-HSA-2730905

Role of LAT2/NTAL/LAB on calcium mobilization

16

102

2,82E-09

R-HSA-76009

Platelet Aggregation (Plug Formation)

11

40

6,74E-09

R-HSA-9679191

Potential therapeutics for SARS

19

164

7,65E-09

R-HSA-372708

p130Cas linkage to MAPK signaling for integrins

8

15

9,06E-09

R-HSA-354194

GRB2:SOS provides linkage to MAPK signaling for Integrins

8

15

9,06E-09

R-HSA-9651496

Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)

8

16

1,49E-08

R-HSA-9671793

Diseases of hemostasis

8

16

1,49E-08

R-HSA-2871809

FCERI mediated Ca + 2 mobilization

16

117

1,55E-08

R-HSA-8963888

Chylomicron assembly

7

10

1,55E-08

R-HSA-8963901

Chylomicron remodeling

7

10

1,55E-08

R-HSA-2871796

FCERI mediated MAPK activation

16

119

1,88E-08

R-HSA-8963899

Plasma lipoprotein remodeling

10

35

2,16E-08

R-HSA-8964058

HDL remodeling

7

11

2,73E-08

R-HSA-5653656

Vesicle-mediated transport

40

762

4,46E-08

R-HSA-983705

Signaling by the B Cell Receptor (BCR)

18

176

1,09E-07

R-HSA-975634

Retinoid metabolism and transport

10

44

1,67E-07

R-HSA-9824443

Parasitic Infection Pathways

21

254

2,17E-07

R-HSA-9658195

Leishmania infection

21

254

2,17E-07

R-HSA-174824

Plasma lipoprotein assembly, remodeling, and clearance

12

76

3,28E-07

R-HSA-6798695

Neutrophil degranulation

29

478

3,29E-07

R-HSA-6806667

Metabolism of fat-soluble vitamins

10

48

3,37E-07

R-HSA-6802948

Signaling by high-kinase activity BRAF mutants

9

37

4,48E-07

R-HSA-446353

Cell-extracellular matrix interactions

7

18

6,28E-07

R-HSA-354192

Integrin signaling

8

28

7,50E-07

R-HSA-5674135

MAP2K and MAPK activation

9

41

1,06E-06

R-HSA-9656223

Signaling by RAF1 mutants

9

42

1,15E-06

R-HSA-2871837

FCERI mediated NF-kB activation

16

167

1,29E-06

R-HSA-9649948

Signaling downstream of RAS mutants

9

47

2,92E-06

R-HSA-6802946

Signaling by moderate kinase activity BRAF mutants

9

47

2,92E-06

R-HSA-6802955

Paradoxical activation of RAF signaling by kinase inactive BRAF

9

47

2,92E-06

R-HSA-6802949

Signaling by RAS mutants

9

47

2,92E-06

R-HSA-198933

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

18

230

4,04E-06

R-HSA-3000480

Scavenging by Class A Receptors

6

19

1,42E-05

R-HSA-5686938

Regulation of TLR by endogenous ligand

6

21

2,51E-05

R-HSA-430116

GP1b-IX-V activation signalling

5

12

2,74E-05

R-HSA-2454202

Fc epsilon receptor (FCERI) signaling

16

218

3,46E-05

R-HSA-6802952

Signaling by BRAF and RAF1 fusions

9

66

3,98E-05

R-HSA-174577

Activation of C3 and C5

4

7

7,74E-05

R-HSA-446388

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

4

8

1,30E-04

R-HSA-2187338

Visual phototransduction

10

100

1,71E-04

R-HSA-977225

Amyloid fiber formation

9

81

1,71E-04

R-HSA-9657689

Defective SERPING1 causes hereditary angioedema

3

3

1,71E-04

R-HSA-9657688

Defective factor XII causes hereditary angioedema

3

3

1,71E-04

R-HSA-6802957

Oncogenic MAPK signaling

9

84

2,24E-04

R-HSA-216083

Integrin cell surface interactions

9

85

2,45E-04

R-HSA-9029569

NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

6

38

5,79E-04

R-HSA-9679506

SARS-CoV Infections

23

509

6,51E-04

R-HSA-1280218

Adaptive Immune System

33

879

7,31E-04

R-HSA-445355

Smooth Muscle Contraction

6

44

1,27E-03

R-HSA-9024446

NR1H2 and NR1H3-mediated signaling

6

48

2,01E-03

R-HSA-3000484

Scavenging by Class F Receptors

3

7

2,05E-03

R-HSA-9662001

Defective factor VIII causes hemophilia A

3

7

2,05E-03

R-HSA-5602498

MyD88 deficiency (TLR2/4)

4

19

3,02E-03

R-HSA-5627117

RHO GTPases Activate ROCKs

4

19

3,02E-03

R-HSA-70263

Gluconeogenesis

5

35

3,23E-03

R-HSA-5603041

IRAK4 deficiency (TLR2/4)

4

20

3,23E-03

R-HSA-1474244

Extracellular matrix organization

15

300

3,23E-03

R-HSA-9668250

Defective factor IX causes hemophilia B

3

9

3,54E-03

R-HSA-159763

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus

3

9

3,54E-03

R-HSA-5627123

RHO GTPases activate PAKs

4

21

3,65E-03

R-HSA-1643685

Disease

59

2101

3,83E-03

R-HSA-70171

Glycolysis

7

80

4,49E-03

R-HSA-3299685

Detoxification of Reactive Oxygen Species

5

39

4,71E-03

R-HSA-381183

ATF6 (ATF6-alpha) activates chaperone genes

3

10

4,79E-03

R-HSA-159782

Removal of aminoterminal propeptides from gamma-carboxylated proteins

3

10

4,79E-03

R-HSA-159740

Gamma-carboxylation of protein precursors

3

10

4,79E-03

R-HSA-196854

Metabolism of vitamins and cofactors

11

192

5,88E-03

R-HSA-159854

Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

3

11

6,28E-03

R-HSA-373755

Semaphorin interactions

6

64

7,36E-03

R-HSA-9636667

Manipulation of host energy metabolism

2

3

7,66E-03

R-HSA-9672391

Defective F8 cleavage by thrombin

2

3

7,66E-03

R-HSA-381033

ATF6 (ATF6-alpha) activates chaperones

3

12

8,04E-03

R-HSA-3000170

Syndecan interactions

4

27

8,07E-03

R-HSA-446728

Cell junction organization

8

118

8,07E-03

R-HSA-75205

Dissolution of Fibrin Clot

3

13

8,07E-03

R-HSA-1236974

ER-Phagosome pathway

7

93

8,40E-03