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Table 2 Two structurally unrelated (Tanimoto similarity coefficient < 20%) assembly modulator chemotypes used in the experiments shown in Fig. 6 are compared for drug-like properties

From: An ALS assembly modulator signature in peripheral blood mononuclear cells: implications for ALS pathophysiology, therapeutics, and diagnostics

Analog representative of chemotype

Molecular weight (g/mol)

log P

H-bond donors

H-bond acceptors

Topological polar surface area (Å2)

Tanimoto similarity coefficient

PAV-073

443.543

4.8

1

5

49

 < 20%

PAV-667

441.915

6.4

0

7

73.7

 < 20%

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Clinical Proteomics

ISSN: 1559-0275